Pharmacology http://dr.lib.sjp.ac.lk/handle/123456789/682024-01-28T20:27:28Z2024-01-28T20:27:28ZIdentification of dengue patients with high risk of severe disease, using early clinical and laboratory features, in a resource-limited settingNiriella, M.ALiyanage, I.KUdeshika, ALiyanapathirana, K.VDe Silva, A.PDe Silva, H.Jhttp://dr.lib.sjp.ac.lk/handle/123456789/90272022-02-24T05:56:15Z2020-01-01T00:00:00ZIdentification of dengue patients with high risk of severe disease, using early clinical and laboratory features, in a resource-limited setting
Niriella, M.A; Liyanage, I.K; Udeshika, A; Liyanapathirana, K.V; De Silva, A.P; De Silva, H.J
Only a minority of dengue infections lead to plasma leakage (critical phase [CP]). Early identification of the risk for CP is
helpful for triage of patients. This study aimed to identify early clinical predictors of CP that will aid in patient triage during
early illness. A retrospective, case-record-based analysis was performed on all microbiologically confirmed (NS 1-antigen- or
dengue-IgM-antibody-positive), dengue patients (n = 697), admitted to our unit from 01.01.2017 to 30.06.2017. Bivariate
analysis was performed to identify clinical and laboratory parameters that predicted CP. Stepwise multivariate logistic
regression with backward elimination (/? < 0.05) was used to identify independent risk factors for CP. CP developed in 226
(32.4%) patients. Mortality was 1.0%. Predictors for CP (p < 0.05) within the first three days included age category 41-50
years (OR = 1.96), females (OR = 2.09), diabetes (OR = 1.30), persistent vomiting (OR = 2.18), platelet count < 120,000/
(OR = 1.91) and AST > 60 IU/L (OR = 3.72). On multivariate analysis, other variables except diabetes remained
significant. Elevated transaminase levels remained the strongest independent predictor of CP (OR 2.83): The. absence of
all five risk factors excluded CP (negative predictive value: 97.2%). Age 41-50 years, female gender, persistent vomiting,
thrombocytopenia, and elevated transaminases were early predictors of CP in dengue fever. The absence of these can be
used to identify patients who may not require hospital admission. Elevated transaminase was the strongest predictor of CP
during early illness.
2020-01-01T00:00:00ZIdentification of dengue patients with high risk of severe disease, using early clinical and laboratory features, in a resource-limited settingNiriella, M.ALiyanage, I.KUdeshika, ALiyanapathirana, K.VDe Silva, A.PDe Silva, H.Jhttp://dr.lib.sjp.ac.lk/handle/123456789/90262020-08-13T09:39:51Z2020-01-01T00:00:00ZIdentification of dengue patients with high risk of severe disease, using early clinical and laboratory features, in a resource-limited setting
Niriella, M.A; Liyanage, I.K; Udeshika, A; Liyanapathirana, K.V; De Silva, A.P; De Silva, H.J
Only a minority of dengue infections lead to plasma leakage (critical phase [CP]). Early identification of the risk for CP is
helpful for triage of patients. This study aimed to identify early clinical predictors of CP that will aid in patient triage during
early illness. A retrospective, case-record-based analysis was performed on all microbiologically confirmed (NS 1-antigen- or
dengue-IgM-antibody-positive), dengue patients (n = 697), admitted to our unit from 01.01.2017 to 30.06.2017. Bivariate
analysis was performed to identify clinical and laboratory parameters that predicted CP. Stepwise multivariate logistic
regression with backward elimination (/? < 0.05) was used to identify independent risk factors for CP. CP developed in 226
(32.4%) patients. Mortality was 1.0%. Predictors for CP (p < 0.05) within the first three days included age category 41-50
years (OR = 1.96), females (OR = 2.09), diabetes (OR = 1.30), persistent vomiting (OR = 2.18), platelet count < 120,000/
(OR = 1.91) and AST > 60 IU/L (OR = 3.72). On multivariate analysis, other variables except diabetes remained
significant. Elevated transaminase levels remained the strongest independent predictor of CP (OR 2.83): The. absence of
all five risk factors excluded CP (negative predictive value: 97.2%). Age 41-50 years, female gender, persistent vomiting,
thrombocytopenia, and elevated transaminases were early predictors of CP in dengue fever. The absence of these can be
used to identify patients who may not require hospital admission. Elevated transaminase was the strongest predictor of CP
during early illness.
2020-01-01T00:00:00ZEmotional intelligence and academic performance of medical undergraduates; a cross-sectional study in a selected university in Sri LankaWijekoon, C.N.Amaratunge, H.Silva, Y.D.Senanayake, S.Jayawardane, P.Senarath, U.http://dr.lib.sjp.ac.lk/handle/123456789/68412022-02-24T05:31:11Z2017-01-01T00:00:00ZEmotional intelligence and academic performance of medical undergraduates; a cross-sectional study in a selected university in Sri Lanka
Wijekoon, C.N.; Amaratunge, H.; Silva, Y.D.; Senanayake, S.; Jayawardane, P.; Senarath, U.
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2017-01-01T00:00:00ZAnti-Hyperglycaemic Effects of Herbal Porridge Made of Scoparia Dulcis Leaf Extract in Diabetics - A Randomized Crossover Clinical TrialSenadheera, S.P.A.S.Ekanayake, S.Wanigatunge, C.A.http://dr.lib.sjp.ac.lk/handle/123456789/39422022-02-24T05:31:43Z2015-01-01T00:00:00ZAnti-Hyperglycaemic Effects of Herbal Porridge Made of Scoparia Dulcis Leaf Extract in Diabetics - A Randomized Crossover Clinical Trial
Senadheera, S.P.A.S.; Ekanayake, S.; Wanigatunge, C.A.
Background: Leaf extracts of Scoparia dulcis, is used as a herbal remedy by diabetics worldwide. Fresh Scoparia dulcis porridge elicited a low glycaemic index (GI) and anti-hyperglycaemic effects when fed to diabetic Wistar rats.
Commercially produced Scoparia dulcis porridge (SDC) elicited medium GI. Present study was aimed at studying the anti-diabetic effects of consumption of commercially produced S dulcis porridge.
Method: A randomized crossover clinical trial with type 2 diabetic patients (n = 35) on medication, with mild and moderate diabetes [fasting blood glucose (FBG) 126-300 mg/dL, age 35-70 years] was conducted. Within the first three months (study period 1) group 1 was the test and group 2 was the control. Following a wash-out period, the two groups were crossed over (study period 2: group 1 - control; group 2 - test). Test group consumed commercially produced SDC for 3 days/week for three months and the control group any other food. At the onset and end of each study period glucose measurements [Fasting Blood Glucose (FBG),HbA 1c], lipid measurements (total cholesterol,
HDL-C, LDL-C, triglycerides, cholesterol ratios), toxicity parameters (liver enzymes, creatinine, CRP, eGFR) were analyzed by enzyme assay kit methods using a KONELAB20XT auto analyzer. Significances between groups were analyzed by one way ANOVA (normal distribution) and Mann Whitney test (if the values were not normally distributed). Within group comparisons were carried out by Bonferroni post hoc test.
Results: During the crossover clinical trial HbA 1c of group 1 decreased from 7.9 ± 0.5 to 6.5 ± 03 (p = 0.003) while
HbA 1c of group 2 decreased from 7.0 ± 03to 6.7 ± 03 while in the test group. Therefore, both test groups (1 and 2) elicited a decrease in HbA 1c compared to respective control groups. Both test groups elicited a non significant decrease in FBG following the intervention (group 1 - from 174± 14 to 160 ± 10 mg/dL; group 2 - from 183± 13 to 160 ± 7 mg/dL). No significant differences (p >0.05) in insulin, cholesterol measurements (total cholesterol, LDL-C,
HDL-C, triglycerides and cholesterol ratios) and atherogenic index between or within groups were observed. All other measurements (AST,ALT, ALP, creatinine, CRP,eGFR) were normal and not significantly different between or within groups.
Conclusion: Porridge made with SDC leaf extract decreased FBG and HbA 1c (p >0.05) of type 2 diabetic patients. The porridge had no effect on cholesterol measurements and no toxicity was observed at the dose tested. Therefore, the SDC porridge can be recommended as a suitable meal for diabetic patients
2015-01-01T00:00:00Z