http://dr.lib.sjp.ac.lk/handle/123456789/62 2025-12-29T04:56:25Z http://dr.lib.sjp.ac.lk/handle/123456789/8376 The role of the unfolded protein response in dengue virus pathogenesis Perera, Nilanka; Miller, Joanna L.; Zitzmann, Nicole Attached 2017-01-01T00:00:00Z http://dr.lib.sjp.ac.lk/handle/123456789/8372 Survey on knowledge of non-alcoholic fatty liver disease (NAFLD) among doctors in Sri Lanka a multicenter study Matthias, A.T.; Fernandopulle, A.N.R.; Seneviratne, S. Attached; Objectives: 1 here has been a global increase in the incidence and prevalence of NAFI.D. We assessed the knowledge and awareness of NAFLD among gastroenterology doctors in three state sector hospitals. 80 medical officers and 58 post-graduate trainee doctors/consultants responded. 110 (79.7%) considered was 10-40%. 52.9% saw 12-24 Results: NAFLD a major health problem whilst 97 (70.3%) thought the prevalence of NAFLD patients with NAFLD/year. A vast majority knew the risk factors for NAFLD: 127 (92.7%) diabetes mellitus 135 (97.8%) Obesity. 132 (95.7%) Dyslipidemia and 87 (63%) PCOS. The methods for diagnosis were recognized by: USS 132 (05 7%) mri 34 (24 6%), transient elastography 23 (16.7%) and liver biopsy 88 (63.8%) while, 53 (38.4%) recognize the non-invasive methods available for diagnosis. The trends in referral were lower than expected: 85 (61.6%) refer to a Gastroenterologist/Physician, 53 (38.4%) to a Gym, 67 (48.6%) to a weight loss clinic and 45 (32.6%) to a dietician Significantly more postgraduate trainee doctors: recognized the availability of non-.nvasive investigations for NAFLD (P = 0.01) and read guidelines on NAFLD (P = 0.02) compared to non-trainee doctors. As a whole, a majority (57.2/o) had not attended a lecture or read a guideline on NAFLD. The barriers for management included: lack of con idence 70 (50.7%) and time constraints 58 (42%). 2018-01-01T00:00:00Z http://dr.lib.sjp.ac.lk/handle/123456789/6772 Acute kidney injury following ingestion of plate developer (sodium metasilicate); a case report Rathnamali, B.G.A.; Samarajiwa, G.; Abeyratne, D.D.K.; Perera, G.N.D.; Gunatilake, S.B. Attached; Background: Plate developer is a chemical used in the printing industry and is a corrosive alkaline agent containing sodium metasilicate as the main substance. Plate developer poisoning is rare. Literature search revealed only a single case report of fatal sodium metasilicate poisoning (Z Rechtsmed 94(3):245—250,1985). There are no reports of acute kidney injury related to ingestion of sodium metasilicate containing substances. Case report: A 52-year-old Sri Lankan male with a history of hypertension and affective disorder presented following ingestion of about 150 ml of plate developer solution. He developed severe upper airway obstruction due to laryngeal edema and underwent tracheostomy. While in the ward he developed features of acute kidney injury with high serum creatinine levels and persistent hyperkalemia which necessitated temporary haemodialysis. Because of the corrosive effect, he developed severe inflammation of the upper gastro intestinal tract with narrowing of esophagus and pyloric region, requiring feeding jejunostomy. He died while waiting for the surgery for pyloric stenosis. Conclusions: Acute kidney injury is a potential treatable complication of plate developer poisoning other than its complications related to corrosive effects. Regular monitoring of renal functions in such a patient would be useful for early recognition of acute kidney injury. 2016-08-22T00:00:00Z http://dr.lib.sjp.ac.lk/handle/123456789/6748 The role of the unfolded protein response in dengue virus pathogenesis Perera, N.; Miller, J.L.; Zitzmann, N. Attached; Symptomatic dengue virus (DENV) infections range from mild fever to severe haemorrhagic disease and death. Host‐viral interactions play a significant role in deciding the fate of the infection. The unfolded protein response (UPR) is a prosurvival cellular reaction induced in response to DENV‐mediated endoplasmic reticulum stress. The UPR has complex interactions with the cellular autophagy machinery, apoptosis, and innate immunity. DENV has evolved to manipulate the UPR to facilitate its replication and to evade host immunity. Our knowledge of this intertwined network of events is continuously developing. A better understanding of the UPR mediated antiviral and proviral effects will shed light on dengue disease pathogenesis and may help development of anti‐DENV therapeutics. This review summarizes the role of the UPR in viral replication, autophagy, and DENV‐induced inflammation to describe how a host response contributes to DENV pathogenesis. 2017-01-01T00:00:00Z