Comparative cytotoxicity of selected cyanotoxins on Human Embryonic Kidney (HEK-293) and Human Kidney Adenocarcinoma (ACHN) Cells.

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2016

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Proceedings of South Asian Regional Conference of the World Organization of Family Doctors, 11th to 14th February 2016, Colombo, Sri Lanka.

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The aim of present study was to evaluate the cytotoxic effects of some selected cyanotoxins namely, MC-LR, MC-RR, MC-LF, MC-LW and Nodularin on normal human kidney cells (HEK-293) and human kidney adenocarcinoma cells (ACHN). Cells were exposed to different concentrations of (1.0–200 μM) cyanotoxin variants for 24 h and the cytotoxic effects were evaluated by Sulphorhodamine B (SRB) assay. Overall findings of the study demonstrate that cyanotoxins could cause cytotoxic effects on kidney cells. MC-LR was the most toxic while MC-LW was least toxic cyanotoxin on both cell types tested. MC-RR, MC-LF and Nodularin had moderate cytotoxicity on human renal cells.

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Piyathilaka, M.A.P.C., Pathmalal, M.M., Tennekoon, K. H., De Silva, B.G.D.N.K. (2016). "Comparative cytotoxicity of selected cyanotoxins on Human Embryonic Kidney (HEK-293) and Human Kidney Adenocarcinoma (ACHN) Cells.", Proceedings of South Asian Regional Conference of the World Organization of Family Doctors, 11th to 14th February 2016, Colombo, Sri Lanka., p. 60

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http://dr.lib.sjp.ac.lk/handle/123456789/6163

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2016 - Applied

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