Antireproductive Effects in Male Rats Exposed to Methamidophos

Abstract

This study examined the reproductive effects of methamidophos, an organophosphorus pesticide on male rats following sub-chronic oral administration (in 3 alternate days). The doses tested were 1.8750 and 0.9375 mg kg"1 day"1 and the reproductive effects were investigated upto 28 - 35 days post-treatment. The results show that both doses of methamidophos inhibited libido in a reversible fashion lasting upto 28 – 35 days. This effect on libido was accompanied by marked depressions in food and water intake, body weight and by cholinergic intoxication. Furthermore, the treatment was reprotoxic: decreased testicular interstitial fluid volume, seminiferous tubular diameter and reduction in motility and numbers of cauda epididymal sperm. Based on these data it is concluded that methamidophos could be detrimental to the sexuality and fertility of men who are constantly exposed to it.