Toxic effects on biochemical and hematological parameters in rats exposed to judo 40.

Abstract

The present study investigated the hematological, and biochemical, changes due to Judo 40 toxicity in male Wistar albino rats. Two sets of male rats (n=9/group) were orally treated with 20 mg/kg and 50 mg/kg of Judo 40 or the vehicle (corn oil) in four fractions for two consecutive days. The first of animals were autopsied on day 1 to assess the liver toxicity while the second set of animals were autopsied on posttreatment day 3 to assess hematological parameters. Both doses of Judo 40 intoxication induced a significant increase in PCV, and WBCs count. Moreover, there was a significant increase in serum biochemical parameters related to hepatic injury: alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP). In general, it was concluded that, Judo 40 could induce hepatotoxicity and alter PCV and WBC counts indicating exposure to Judo 40 could pose risk to human health.