Cytotoxic and Noncytotoxic Metabolites from Teratosphaeria sp. FL2137, a Fungus Associated with Pinus clausa

Simple item page
dc.contributor.authorPadurnadasa, C.
dc.contributor.authorXu, Y.M.
dc.contributor.authorWijeratne, E.M.K.
dc.contributor.authorArtiles, P.E.
dc.contributor.authorU'Ren, J.M.
dc.contributor.authorArnold, A.E.
dc.contributor.authorGunatilaka, A.A.L.
dc.date.accessioned2018-07-04T04:34:36Z
dc.date.available2018-07-04T04:34:36Z
dc.date.issued2018-01-26
dc.description.abstractAttacheden_US
dc.description.abstractA new naphthoquinone, teratosphaerone A (I), four new naphthalenones, namely, teratosphaerone B (2), structurally related to I, iso-balticol B (3), iso-balticol B-4,9-acetonide (4), and (+)-balticol C (5), a new furanonaphthalenone, (3aS,9R,9aS)-1(9a),3(3a),9-hexahydromonosporascone (6), and the known metabolite monosporascone (7) were isolated from Teratosphaeria sp. FL2137, a fungal strain inhabiting the internal tissue of recently dead but undecomposed foliage of Pinus clausa. The structures of 1-6 were elucidated on the basis of their spectroscopic data including 2D NMR, and absolute configurations of 2, 3, and 6 were determined by the modified Mosher's ester method. When evaluated in a panel of five tumor ceIJlines, metabolites 1 and 7 isolated from a cytotoxic fraction of the extract exhibited moderate selectivity for metastatic breast adenocarcinoma cell line MDA-MB-231. Of these, 1 showed cytotoxicity to this cell line with an ICso of 1.2 ± 0.1 JiM.
dc.identifier.citationPadurnadasa, C., Xu, Y.M., Wijeratne, E.M.K., Artiles, P.E., U'Ren, J.M., Arnold, A.E., Gunatilaka, A.A.L. (2018). "Cytotoxic and Noncytotoxic Metabolites from Teratosphaeria sp. FL2137, a Fungus Associated with Pinus clausa", Journal of Natural Products, Vol. 81, pp. 616-624en_US
dc.identifier.urihttp://dr.lib.sjp.ac.lk/handle/123456789/7005
dc.publisherJournal of Natural Productsen_US
dc.titleCytotoxic and Noncytotoxic Metabolites from Teratosphaeria sp. FL2137, a Fungus Associated with Pinus clausaen_US
dc.typeArticleen_US

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
Cytotoxic and Noncytotoxic Metabolites from Teratosphaeria sp. FL2137, a Fungus Associated with Pinus clausa.pdf
Size:
7.56 MB
Format:
Adobe Portable Document Format
Description:
Download

License bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Information Resources on Chemistry