Comparative Cytotoxicity of Selected Cyanotoxins on Human Embryonic Kidney (HEK-293) and Human Kidney Adenocarcinoma (ACHN) Cells

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dc.contributor.authorPiyathilaka, P.C.
dc.contributor.authorTennekoon, K.H.
dc.contributor.authorDe Silva, N.K.
dc.contributor.authorManage, P.M.
dc.date.accessioned2016-09-26T08:15:13Z
dc.date.available2016-09-26T08:15:13Z
dc.date.issued2016-09-26T08:15:13Z
dc.date.published2016
dc.description.abstractThe aim of present study was to evaluate the cytotoxic effects of some selected cyanotoxins namely, MC-LR, MC-RR, MC-LF, MC-LW and Nodularin on normal human kidney cells (HEK-293) and human kidney adenocarcinoma cells (ACHN). Cells were exposed to different concentrations of (1.0–200 μM) cyanotoxin variants for 24 h and the cytotoxic effects were evaluated by Sulphorhodamine B (SRB) assay. Overall findings of the study demonstrate that cyanotoxins could cause cytotoxic effects on kidney cells. MC-LR was the most toxic while MC-LW was least toxic cyanotoxin on both cell types tested. MC-RR, MC-LF and Nodularin had moderate cytotoxicity on human renal cells.en_US
dc.identifier.citationPiyathilaka, P.C., Tennekoon, K.H., De Silva, N.K., & Manage, P.M. (2016). Comparative Cytotoxicity of Selected Cyanotoxins on Human Embryonic Kidney (HEK-293) and Human Kidney Adenocarcinoma (ACHN) Cells. ISOI Journal of Microbiology, Biotechnology And Food Science, 2(1), 45-49.
dc.identifier.issn2395-6887
dc.identifier.urihttp://dr.lib.sjp.ac.lk/handle/123456789/2947
dc.language.isoenen_US
dc.subjectCytotoxicityen_US
dc.subjectACHN cellsen_US
dc.subjectHEK-293 cellsen_US
dc.subjectSRBen_US
dc.subjectCyanotoxins.en_US
dc.titleComparative Cytotoxicity of Selected Cyanotoxins on Human Embryonic Kidney (HEK-293) and Human Kidney Adenocarcinoma (ACHN) Cellsen_US
dc.typeArticleen_US

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