Rhinovirus Infection in Children—a Narrative Review

Abstract

First discovered in the 1950s, rhinoviruses (RVs) are linked to a broad spectrum of clinical syndromes, particularly in young children. RVs cause greater morbidity than previously recognized and impose substantial health care expenditure and missed days of work due to physician visits, hospitalization, and childcare. Our understanding of the genomic structure of RVs has increased with advances in molecular methods. RT-PCR is the most commonly used method for RV detection at present. Currently, treatment of RV infection is mostly supportive; there are no approved antiviral medications available yet. This review aims to provide the most current information on clinical syndromes, pathogenesis, host immunological responses, diagnostics, and therapeutic and preventive strategies related to RV infection in children