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Gastroprotective Activity of Patoladi Decoction in Rats

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dc.contributor.author Munasinghe, S.L.
dc.contributor.author Vithanage, D.K.
dc.contributor.author Ratnasooriya, W.D.
dc.date.accessioned 2013-04-26T07:59:53Z
dc.date.available 2013-04-26T07:59:53Z
dc.date.issued 2002
dc.identifier.citation Munasinghe, S.L., Vithanage, D.K., & Ratnasooriya, W.D. (2002). Gastroprotective Activity of Patoladi Decoction in Rats. Vidyodaya Journal of Science, 11, 47-55. en-US
dc.identifier.uri http://dr.lib.sjp.ac.lk/handle/123456789/1023
dc.description.abstract In one of the Ayurvedic treatise' Patoladi' decoction (PD) consisting of five ingredients (Terminalia chebula Retz, Terminalia belerica Roxb, Phyllenthus emblica Linn. Tricosenthes cucumarina Linn. Azadirachta indica A. Juss.) is recommended for the treatment of' Amlapitta ' (dyspepsia/gastritis). This indicates that PD may posses gastro protective action. The aim of this study was to investigate this possibility in rats using ethanol-induced gastric lesions. Different concentrations of freshly prepared PD was either orally [30% (n=6), 15% (n=6), 7.5% (n=6) or 0% (n=6)] or IP [30% (n=6), 7.5% (n=6) or 0% (n=6)] administered to fasted rats. 30 min later, 1ml of absolute ethanol was either orally or IP administered to these rats and Ih later the number and length of gastric linear haemorrhagic lesions were determined. The results show that both treatments of PD markedly and significantly impaired the number and the length of gastric lesions. The PD did not significantly alter the volume, pH, free and total acidity and peptic activity of the gastric content. But, it caused significant increase in carbohydrate and mucus content of the gastric mucus layer. This may be the main mechanism of action of PD. We conclude that PD has potent gastroprotective action and may be therapeutically useful in the treatment of' Amlapitta' in Ayurvedic Medicine in Sri Lanka. en_US
dc.language.iso en en_US
dc.subject Patoladi decoction en_US
dc.subject Dyspepsia en_US
dc.subject Gastritis en_US
dc.subject Gastric lesions en_US
dc.subject Gastroprotection en_US
dc.subject Ayurveda en_US
dc.subject Sri Lanka en_US
dc.title Gastroprotective Activity of Patoladi Decoction in Rats en_US
dc.type Article en_US
dc.date.published 2002

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