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Cytoskeletal Pathologies of Age-Related Diseases between Elderly Sri Lankan (Colombo) and Indian (Bangalore) Brain Samples

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dc.contributor.author De Silva, K. Ranil D.
dc.contributor.author Wijesinghe, Printha
dc.contributor.author Shankar, S.K.
dc.contributor.author Chickabasaviah, Yasha T.
dc.contributor.author Gorrie, Catherine
dc.contributor.author Amaratunga, Dhammika
dc.contributor.author Hulathduwa, Sanjayah
dc.contributor.author Kumara, K. Sunil
dc.contributor.author Samarasinghe, Kamani
dc.contributor.author Suh, Yoo Hun
dc.contributor.author Steinbusch, H.W.
dc.date.accessioned 2016-05-18T01:58:32Z
dc.date.available 2016-05-18T01:58:32Z
dc.date.issued 2016-05-18T01:58:32Z
dc.identifier.citation De Silva, K.R.D., Wijesinghe, P., Shankar, S.K., Chickabasaviah, Y.T., Gorrie, C., Amaratunga, D., Hulathduwa, S., Kumara, K.S., Samarasinghe, K., Suh, Y.H., & Steinbusch, H.W. (2016). Cytoskeletal Pathologies of Age-Related Diseases between Elderly Sri Lankan (Colombo) and Indian (Bangalore) Brain Samples. Current Alzheimer Research, 13, 268-280.
dc.identifier.uri http://hdl.handle.net/123456789/2773
dc.description.abstract Within South Asia, Sri Lanka represents fastest aging with 13% of the population was aged over 60’s in 2011, whereas in India it was 8%. Majority of the Sri Lankan population based genetic studies have confirmed their origin on Indian mainland. As there were inadequate data on aging cytoskeletal pathologies of these two nations with their close genetic affiliations, we performed a comparison on their elderly. Autopsy brain samples of 50 individuals from Colombo, Sri Lanka (mean age 72.1yrs ± 7.8, mean ± S.D.) and 42 individuals from Bangalore, India (mean age 65.9yrs ± 9.3) were screened for neurodegenerative pathologies using immunohistochemical techniques. A total of 79 cases with incomplete clinical history (Colombo- 47 and Bangalore- 32) were subjected to statistical analysis and 13 cases, clinically diagnosed with dementia and/or Parkinsonism disorders were excluded. As per National Institute on Aging- Alzheimer’s Association guidelines, between Colombo and Bangalore samples, Alzheimer’s disease neuropathologic change for intermediate/ high level was 4.25% vs. 3.12% and low level was 19.15% vs. 15.62% respectively. Pathologies associated with Parkinsonism including brainstem predominant Lewy bodies- 6.4% and probable progressive supra nuclear palsy- 2.13% were found solely in Colombo samples. Alzheimer related pathologies were not different among elders, however, in Colombo males, neurofibrillary tangle grade was significantly higher in the region of hippocampus (odds ratio = 1.46, 95% confidence interval = 0.07-0.7) and at risk in midbrain substantia nigra (p = 0.075). Other age-related pathologies including spongiform changes (p < 0.05) and hippocampus cell loss in dentate gyrus region (p < 0.05) were also identified prominently in Colombo samples. Taken together, aging cytoskeletal pathologies are comparatively higher in elderly Sri Lankans and this might be due to their genetic, dietary and/ or environmental variations. en_US
dc.language.iso en en_US
dc.subject AD neuropathologic change en_US
dc.subject cell loss en_US
dc.subject immunohistochemistry en_US
dc.subject parkinsonism en_US
dc.subject south asia en_US
dc.subject spongiform changes en_US
dc.title Cytoskeletal Pathologies of Age-Related Diseases between Elderly Sri Lankan (Colombo) and Indian (Bangalore) Brain Samples en_US
dc.type Article en_US
dc.date.published 2016

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