Comparative Cytotoxicity of Selected Cyanotoxins on Human Embryonic Kidney (HEK-293) and Human Kidney Adenocarcinoma (ACHN) Cells

dc.contributor.author	Piyathilaka, P.C.
dc.contributor.author	Tennekoon, K.H.
dc.contributor.author	De Silva, N.K.
dc.contributor.author	Manage, P.M.
dc.date.accessioned	2016-09-26T08:15:13Z
dc.date.available	2016-09-26T08:15:13Z
dc.date.issued	2016-09-26T08:15:13Z
dc.identifier.citation	Piyathilaka, P.C., Tennekoon, K.H., De Silva, N.K., & Manage, P.M. (2016). Comparative Cytotoxicity of Selected Cyanotoxins on Human Embryonic Kidney (HEK-293) and Human Kidney Adenocarcinoma (ACHN) Cells. ISOI Journal of Microbiology, Biotechnology And Food Science, 2(1), 45-49.
dc.identifier.issn	2395-6887
dc.identifier.uri	http://dr.lib.sjp.ac.lk/handle/123456789/2947
dc.description.abstract	The aim of present study was to evaluate the cytotoxic effects of some selected cyanotoxins namely, MC-LR, MC-RR, MC-LF, MC-LW and Nodularin on normal human kidney cells (HEK-293) and human kidney adenocarcinoma cells (ACHN). Cells were exposed to different concentrations of (1.0–200 μM) cyanotoxin variants for 24 h and the cytotoxic effects were evaluated by Sulphorhodamine B (SRB) assay. Overall findings of the study demonstrate that cyanotoxins could cause cytotoxic effects on kidney cells. MC-LR was the most toxic while MC-LW was least toxic cyanotoxin on both cell types tested. MC-RR, MC-LF and Nodularin had moderate cytotoxicity on human renal cells.	en_US
dc.language.iso	en	en_US
dc.subject	Cytotoxicity	en_US
dc.subject	ACHN cells	en_US
dc.subject	HEK-293 cells	en_US
dc.subject	SRB	en_US
dc.subject	Cyanotoxins.	en_US
dc.title	Comparative Cytotoxicity of Selected Cyanotoxins on Human Embryonic Kidney (HEK-293) and Human Kidney Adenocarcinoma (ACHN) Cells	en_US
dc.type	Article	en_US
dc.date.published	2016