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Clozapine induced pancytopenia leading to severe sepsis: an unusual early complication

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dc.contributor.author Pushpakumara,J.
dc.contributor.author Karunarathna,P.
dc.contributor.author Sivathiran,S.
dc.contributor.author Liyanage,A.
dc.contributor.author Indrakumar,J.
dc.date.accessioned 2016-12-16T08:06:43Z
dc.date.available 2016-12-16T08:06:43Z
dc.date.issued 2015-12-16
dc.identifier.citation Pushpakumara,J.,Karunarathna,P.,Sivathiran,S.,Liyanage,A.,Indrakumar,J.,(2015) "Clozapine induced pancytopenia leading to severe sepsis: an unusual early complication", BMC Research Notes en_US, si_LK
dc.identifier.issn 1756-0500
dc.identifier.uri http://dr.lib.sjp.ac.lk/handle/123456789/3532
dc.description.abstract Background: Clozapine is a second generation antipsychotic used to treat resistant schizophrenia and other psychotic illnesses. Leucopenia or agranulocytosis is a rare side effect of this drug. Pancytopenia is an extremely rare side effect of clozapine and literature review showed only one such case in where the pancytopenia developed several months after starting clozapine together with other antipsychotic drugs. Case presentation: A 26-year-old Sri Lankan male was admitted with fever for 3 days. Apart from generalized body aches there were no other significant symptoms. His blood counts showed pancytopenia. He was being treated for a resistant schizophrenia and clozapine was started only 4 weeks before. Common causes for pancytopenia were excluded, and a diagnosis of clozapine induced pancytopenia was made. He was managed in the intensive care unit with broad spectrum antibiotics, antifungals and granulocyte colony stimulating factors. He made a complete recovery after 4 weeks. Conclusion: This is a rare and probably the first reported case of early onset clozapine induced pancytopenia complicated by severe sepsis recovering completely. en_US, si_LK
dc.language.iso en_US en_US, si_LK
dc.publisher BioMed Central (BMC), United Kingdom en_US, si_LK
dc.subject Clozapine en_US, si_LK
dc.subject Pancytopenia en_US, si_LK
dc.title Clozapine induced pancytopenia leading to severe sepsis: an unusual early complication en_US, si_LK
dc.type Article en_US, si_LK

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