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Molecular Characterisation and Disease Severity of Leptospirosis in Sri Lanka

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dc.contributor.author Bandara, K.K.
dc.contributor.author Weerasekera, M.
dc.contributor.author Gunasekara, C.P.
dc.contributor.author Ranasinghe, N.
dc.contributor.author Marasinghe, C.
dc.contributor.author Fernando, N.
dc.date.accessioned 2017-03-15T08:49:09Z
dc.date.available 2017-03-15T08:49:09Z
dc.date.issued 2015
dc.identifier.citation Bandara, K.K., Weerasekera, M., Gunasekara, C.P., Ranasinghe, N., Marasinghe, C., & Fernando, N. (2015). Molecular Characterisation and Disease Severity of Leptospirosis in Sri Lanka. Mem Inst Oswaldo Cruz, Rio de Janeiro, 110(4), 1-7. doi: 10.1590/0074-02760150070 en_US, si_LK
dc.identifier.issn 0074-0276 (print) 1678-8060 (online)
dc.identifier.uri http://dr.lib.sjp.ac.lk/handle/123456789/4429
dc.description.abstract Leptospirosis is a re-emerging zoonotic disease all over the world, important in tropical and subtropical areas. A majority of leptospirosis infected patients present as subclinical or mild disease while 5-10% may develop severe infection requiring hospitalisation and critical care. It is possible that several factors, such as the infecting serovar, level of leptospiraemia, host genetic factors and host immune response, may be important in predisposition towards severe disease. Different Leptospira strains circulate in different geographical regions contributing to variable disease severity. Therefore, it is important to investigate the circulating strains at geographical locations during each outbreak for epidemiological studies and to support the clinical management of the patients. In this study immunochromatography, microscopic agglutination test and polymerase chain reaction were used to diagnose leptospirosis. Further restriction fragment length polymorphism and DNA sequencing methods were used to identify the circulating strains in two selected geographical regions of Sri Lanka. Leptospira interrogans, Leptospira borgpetersenii and Leptospira kirschneri strains were identified to be circulating in western and southern provinces. L. interrogans was the predominant species circulating in western and southern provinces in 2013 and its presence was mainly associated with renal failure. en_US, si_LK
dc.language.iso en en_US, si_LK
dc.subject Leptospira en_US, si_LK
dc.subject molecular characterisation en_US, si_LK
dc.subject Sri Lanka en_US, si_LK
dc.title Molecular Characterisation and Disease Severity of Leptospirosis in Sri Lanka en_US, si_LK
dc.type Article en_US, si_LK

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