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Environmental and Occupational Exposures as a Cause of Male Infertility

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dc.contributor.author Wijesekara, G.U.S.
dc.contributor.author Fernando, D.M.S.
dc.contributor.author Wijerathna, S.
dc.contributor.author Bandara, N.
dc.date.accessioned 2017-03-20T09:23:11Z
dc.date.available 2017-03-20T09:23:11Z
dc.date.issued 2015
dc.identifier.citation Wijesekara, G.U.S., Fernando, D.M.S., Wijerathna, S., & Bandara, N. (2015). Environmental and Occupational Exposures as a Cause of Male Infertility. Ceylon Medical Journal, 60(2), 52-56. en_US, si_LK
dc.identifier.issn 2386-1274
dc.identifier.uri http://dr.lib.sjp.ac.lk/handle/123456789/4450
dc.description.abstract Objectives: To determine the association between environmental and occupational exposures, semen parameters and lead (Pb) and cadmium (Cd) levels in seminal plasma of men investigated for infertility. Methods Data were collected from 300 men investigated for infertility using an interviewer administered questionnaire. Seminal fluid analysis and classification was done according to WHO guidelines. Positive exposure was defined as environmental or occupational exposure to agro or industrial chemicals, heavy metals and living in areas within 50m of potential sources of pollution for three months or more. Seminal plasma lead and cadmium levels were estimated by graphite furnace atomic absorption spectrophotometry after digestion with nitric acid. The means of sperm parameters, Pb and Cd concentrations between exposed and non exposed groups were compared using t-test. Results Mean age was 34.8 (95% CI 34.2-35.4) years BMI was 24.3 (95% CI 23.8-24.7) kg/m2 and duration of the infertility was 45.7 (41.7-49.6) months. In this study, 54.6% were exposed to toxins through environmental or occupational sources. All sperm parameters were lower in the exposed group when compared to the non exposed. Lead and cadmium were detected in 38.3% and 23% of men respectively. The distance from the source of possible environmental or occupational exposure was negatively correlated to seminal plasma Pb (r=0.06, p>0.05) and Cd (r=0.26, p<0.05) concentrations. In the exposed, mean lead concentration was 17.7 (95% CI 15.0-20.4) µg/dl and 13.5 (95% CI 11.2-15.7) µg/dl in non exposed and cadmium concentration in exposed was 1.2 (95% CI 1.1- 1.4) µg/dl and 1.1 (0.9-1.3) µg/dl in non-exposed. Conclusions Environmental and occupational exposures were associated with reduced sperm count motility, viability, normal forms and detectable levels of lead and cadmium in seminal plasma. en_US, si_LK
dc.language.iso en en_US, si_LK
dc.publisher Sri Lanka Medical Association en_US, si_LK
dc.subject environmental and occupational exposure en_US, si_LK
dc.subject lead/cadmium in seminal plasma en_US, si_LK
dc.subject semen parameters en_US, si_LK
dc.title Environmental and Occupational Exposures as a Cause of Male Infertility en_US, si_LK
dc.type Article en_US, si_LK


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