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Synthesis and characterization of novel rhenium(I) complexes towards potential biological imaging applications

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dc.contributor.author Ranasinghe, K.
dc.contributor.author Handunnetti, S.
dc.contributor.author Perera, I.C.
dc.contributor.author Perera, T.
dc.date.accessioned 2017-10-10T02:29:13Z
dc.date.available 2017-10-10T02:29:13Z
dc.date.issued 2016-11-25
dc.identifier.citation Ranasinghe, K., Handunnetti, S., Perera, I.C., Perera, T. (2016). "Synthesis and characterization of novel rhenium(I) complexes towards potential biological imaging applications", Chemistry Central Journal, Vol.10 (71), 1-10 pp. en_US, si_LK
dc.identifier.uri http://dr.lib.sjp.ac.lk/handle/123456789/5720
dc.description.abstract Attached en_US, si_LK
dc.description.abstract Background: Re(I) tricarbonyl complexes exhibit immense potential as fluorescence imaging agents. However, only a handful of rhenium complexes have been utilized in biological imaging. The present study describes the synthesis of four novel rhenium complexes, their characterization and preliminary biological studies to assess their potential as biological imaging agents. Results: Four facial rhenium tricarbonyl complexes containing a pyridyl triazine core, (L1 = 5,5′(3-(2-pyridyl)-1,2,4- triazine-5,6-diyl)-bis-2-furansulfonic acid disodium salt and L2 = (3-(2- pyridyl)-5,6-diphenyl-1,2,4-triazine-4′,4′′- disulfonic acid sodium salt) have been synthesized by utililzing two different Re metal precursors, Re(CO)5Br and [Re(CO)3(H2O)3]OTf in an organic solvent mixture and water, respectively. The rhenium complexes [Re(CO)3(H2O) L1]+ (1), Re(CO)3L1Br (2), [Re(CO)3(H2O)L2]+ (3), and Re(CO)3L2Br (4), were obtained in 70–85% yield and characterized by 1 H NMR, IR, UV, and luminescence spectroscopy. In both H2O and acetonitrile, complexes display a weak absorption band in the visible region which can be assigned to a metal to ligand charge transfer excitation and fluorescent emission lying in the 650–710 nm range. Cytotoxicity assays of complexes 1, 3, and 4 were carried out for rat peritoneal cells. Both plant cells (Allium cepa bulb cells) and rat peritoneal cells were stained using the maximum non-toxic concentration levels of the compounds, 20.00 mg ml−1 for 1 and 3 and 5.00 mg ml−1 for 4 to observe under the epifluorescence microscope. In both cell lines, compound concentrated specifically in the nuclei region. Hence, nuclei showed red fluorescence upon excitation at 550 nm. Conclusions: Four novel rhenium complexes have been synthesized and characterized. Remarkable enhancement of fluorescence upon binding with cells and visible range excitability demonstrates the possibility of using the new complexes in biological applications.
dc.language.iso en_US en_US, si_LK
dc.publisher Chemistry Central Journal en_US, si_LK
dc.subject Rhenium tricarbonyl en_US, si_LK
dc.subject NMR spectroscopy en_US, si_LK
dc.subject Cytotoxicity en_US, si_LK
dc.subject Fluorescent en_US, si_LK
dc.title Synthesis and characterization of novel rhenium(I) complexes towards potential biological imaging applications en_US, si_LK
dc.type Article en_US, si_LK


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