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Presence of Obstetrics Cholestasis in Mothers Presenting with Pruritus in Pregnancy; In a Low Resource South Asian Setting

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dc.contributor.author Dodampahala, S.H.
dc.contributor.author Pieris, H.
dc.contributor.author Chandrasena, L.G.
dc.contributor.author Jayakody, S.
dc.contributor.author Gunathilaka, C.
dc.contributor.author Wijayaratne, C.N.
dc.contributor.author Dodampahala, G.S.K.
dc.contributor.author Meegahawatta, A.R.
dc.date.accessioned 2017-11-06T08:00:37Z
dc.date.available 2017-11-06T08:00:37Z
dc.date.issued 2016-05-09
dc.identifier.citation Dodampahala, S.H., Pieris, H., Chandrasena, L.G., Jayakody, S., Gunathilaka, C., Wijayaratne, C.N., Dodampahala, G.S.K., Meegahawatta, A.R. (2016). "Presence of Obstetrics Cholestasis in Mothers Presenting with Pruritus in Pregnancy; In a Low Resource South Asian Setting", Advances in Reproductive Sciences, Vol.4, pp. 37-45 en_US, si_LK
dc.identifier.uri http://dr.lib.sjp.ac.lk/handle/123456789/6518
dc.description.abstract Attached en_US, si_LK
dc.description.abstract Obstetric cholestasis (also referred to as intrahepatic cholestasis of pregnancy—ICP) is a pruritic form of reversible cholestasis that is associated with significant fetal risks. There is a paucity of research regarding pregnancy outcomes of the mothers with obstetric cholestasis in the South Asian setting. Hence, the objective of this study was to determine the prevalence of obstetric cholestasis among mothers presenting with pruritus during pregnancy and to describe the characteristics and outcomes for those diagnosed with ICP in comparison with those with pruritus in the absence of ICP. Methods: All mothers presenting with pruritus to De Soyza Maternity hospital in Colombo Sri Lanka, between 1st January 2011 to 1st january 2014, were recruited for the study. A standard set of biochemical tests were used for diagnosis of ICP. An interviewer administered questionnaire and patient records were used for data collection. Presentation, characteristics and pregnancy outcomes were assessed and compared for mothers with ICP against those with pruri-tus in the absence of ICP. Results: The prevalence of ICP in the study population was found to be 27% (n = 27), Generalized pruritus with pruritus of the palms and soles was identified as the common* est pattern of pruritus for diagnosed with ICP. Delivery before 37 weeks (p = 0.001), meconium stained liquor (p = 0.004), placental abruption (p = 0.005). postpartum hemorrhage (p = 0.005), bleeding manifestation (p = 0.006), preterm labor (p = 0.031) and fetal distress (p = 0.035) were found to be significantly associated with the presence of ICP. Conclusions: Nearly 1/3 of mothers presenting with pruritus in pregnancy in Sri Lanka are affected by ICP which is associated with an increase in a wide range of adverse maternal and fetal outcomes compared to those with pruritus in the absence of ICP.
dc.language.iso en_US en_US, si_LK
dc.publisher Advances in Reproductive Sciences en_US, si_LK
dc.subject Bile Acid en_US, si_LK
dc.subject Intrahepatic Cholestasis en_US, si_LK
dc.subject Liver Disease en_US, si_LK
dc.subject Pregnancy Complications en_US, si_LK
dc.subject Pruritus en_US, si_LK
dc.title Presence of Obstetrics Cholestasis in Mothers Presenting with Pruritus in Pregnancy; In a Low Resource South Asian Setting en_US, si_LK
dc.type Article en_US, si_LK


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