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Effect of three edible oils on the intestinal absorption of caffeic acid an in vivo and in vitro study

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dc.contributor.author Prasadan, W.C.
dc.contributor.author Senanayake, C.M.
dc.contributor.author Jayathilaka, N.
dc.contributor.author Ekanayake, S.
dc.contributor.author Seneviratne, K.N.
dc.date.accessioned 2018-11-21T08:07:55Z
dc.date.available 2018-11-21T08:07:55Z
dc.date.issued 2017-06-15
dc.identifier.citation Prasadan, W.C. et al., (2017). "Effect of three edible oils on the intestinal absorption of caffeic acid an in vivo and in vitro study", Plos One, Vol.12 (6), pp. 1-11 en_US
dc.identifier.uri http://dr.lib.sjp.ac.lk/handle/123456789/7576
dc.description.abstract Polyphenolic antioxidants are mainly absorbed through passive paracellular permeation regulated by tight junctions. Some fatty acids are known to modulate tight junctions. Fatty acids resulting from the digestion of edible oils may improve the absorption of polyphenolic antioxidants. Therefore, we explored the effect of three edible oils on the intestinal absorption of caffeic acid. Rats were fed with soybean oil and caffeic acid dissolved in distilled water. Caffeic acid contents in the plasma collected up to 1 hr were quantified. The experiment was repeated with coconut oil and olive oil. Component fatty acids of the oils were individually tested in vitro for their effect on permeability of caffeic acid using Caco-2 cell monolayers. Highest absorption of caffeic acid was observed in animals fed with coconut oil. In vitro transport percentages of caffeic acid in 2.5 mmol/L solutions of fatty acids were 22.01±0.12 (lauric), 15.30 ± 0.25 (myristic acid), 13.59 ± 0.35 (linoleic acid), 3.70 ± 0.09 (oleic acid) and 0.10±2.0 (all other fatty acids). Lauric acid and myristic acid are the two major fatty acids present in coconut oil. Therefore, these fatty acids may contribute to the higher absorption of caffeic acid in the presence of coconut oil. en_US
dc.language.iso en en_US
dc.publisher Creative Commons Attribution License en_US
dc.title Effect of three edible oils on the intestinal absorption of caffeic acid an in vivo and in vitro study en_US
dc.type Article en_US
dc.identifier.doi 10.1371/journal.pone.0179292 en_US


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