Effect of Methanolic Extract of Abrus precatorius Seeds on Fertility of Female Rats

dc.contributor.author	Ratnasooriya, W.D.
dc.contributor.author	Amarasekara, A.S.
dc.contributor.author	Ananda, U.V.D.S.
dc.date.accessioned	2013-02-27T08:50:00Z
dc.date.available	2013-02-27T08:50:00Z
dc.date.issued	1991
dc.identifier.citation	Ratnasooriya, W.D., Amarasekara, A.S., & Ananda, U.V.D.S. (1991). Effect of Methanolic Extract of Abrus precatorius Seeds on Fertility of Female Rats. Vidyodaya Journal of Science, 3(2), 41-46.	en-US
dc.identifier.uri	http://dr.lib.sjp.ac.lk/handle/123456789/800
dc.description.abstract	This study examines the post-coital contraceptive potential of a methanolic extract of Abrus precatorius seeds using albino rats. The major constituent of this extract was found to be abrin, an amino acid derivative (68 % by weight). Furthermore, the extract had no steroidal constituents. Oral administration of the extract using various dose and time -regimens (single dose of 150mg Ikg on day I of pregnancy; twice daily dose of 150mglkg on day 1 of pregnancy; a single dose of 300mglkg, on day 1 of pregnancy; and 300mglkg dose from day 1-7 of pregnancy) did not suppress fertility significantly. However, a tendency towards foetal aggregation was evident. It is concluded that the polar fractions of this seed (presumably abrin), has very little potential as a post-coital contraceptive agent.	en_US
dc.language.iso	en	en_US
dc.subject	methanolic extract	en_US
dc.subject	Abrus precatorius seeds	en_US
dc.subject	fertility	en_US
dc.subject	rats	en_US
dc.title	Effect of Methanolic Extract of Abrus precatorius Seeds on Fertility of Female Rats	en_US
dc.type	Article	en_US