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Commercial Formulation of Chlorpyrifos Alters Neurological Behaviors and Fertility

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dc.contributor.author Kudavidanage, E.P
dc.contributor.author Dissanayake, D.M.I
dc.contributor.author Keerthirathna, W.L.R
dc.contributor.author Nishshanke, N.L.W
dc.contributor.author Peiris, L.D.C
dc.date.accessioned 2020-05-14T09:43:12Z
dc.date.available 2020-05-14T09:43:12Z
dc.date.issued 2020
dc.identifier.citation Kudavidanage, E.P, et al.(2020)."Commercial Formulation of Chlorpyrifos Alters Neurological Behaviors and Fertility ", Biology 2020, 9, 49. en_US
dc.identifier.uri http://dr.lib.sjp.ac.lk/handle/123456789/8925
dc.description.abstract Pesticides are known to result in toxic insult. We aimed to evaluate Judo 40, the commercial formulation of chlorpyrifos on the neurological activities, fertility, and hormone levels of male rats. Male Wistar rats were treated orally with 1 mL of 20 or 50 mg/kg Judo 40. The doses were administered four times, twice a day. Sexual and exploratory behavior indices, fertility indices, serum androgen levels, blood acetylcholinesterase (BChE) levels, and neurological and muscular effects were evaluated. Serum testosterone and luteinizing hormone were significantly reduced in the rats receiving 50 mg/kg Judo 40. A reduction in viable implantation sites and live pups born were evident in the female rats mated with the male rats treated with the highest dose. Similarly, in the rats treated with the highest dose of Judo 40, a significant reduction in plasma BChE enzyme was observed. According to the results, prolonged Judo 40 exposure can cause impairment of the neurological alterations and sex hormones leading to impaired fertility. Therefore, chemical handlers should be educated on protection and risk minimization. en_US
dc.language.iso en en_US
dc.subject Judo 40; chemical formulation; chlorpyrifos; organophosphate; sexual behavior; pain perception; fertility index en_US
dc.title Commercial Formulation of Chlorpyrifos Alters Neurological Behaviors and Fertility en_US
dc.type Article en_US
dc.identifier.doi 10.3390/biology9030049 en_US

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