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Role of Staphylococcus aureus in Atopic Dermatitis

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dc.contributor.author Gomes, P.L.R.
dc.contributor.author Malavige, G.N.
dc.contributor.author Fernando, N.
dc.date.accessioned 2013-03-20T09:11:58Z
dc.date.available 2013-03-20T09:11:58Z
dc.date.issued 2009
dc.identifier.citation Gomes, P.L.R., Malavige, G.N., & Fernando, N. (2009). Role of Staphylococcus aureus in Atopic Dermatitis. Vidyodaya Journal of Humanities and Social Science (Joint Golden Jubilee Issue), 45-52. en-US
dc.identifier.uri http://dr.lib.sjp.ac.lk/handle/123456789/934
dc.description.abstract Atopic dermatitis (AD) is a chronic relapsing. itchy inflammatory condition of the skin usually associated with other allergic diseases such as asthma and hay fever. Following the initial occurrence of AD several factors such as environmental allergens, colonization with Staphylococcus aureus and allergen specific T cell responses are though, to aggravate the disease. The bacteria skin flora of patients wit h atopic dermatitis is strikingly different from that in healthy people in terms of the presence of Staphylococcus aureus. An altered epidermal barrier; increased bacterial adhesion, defective bacterial clearance and defective cutaneous innate immune response are among various factors contributing to this high bacterial colonization inAD Staphylococcus aureus strains with ability to secrete Staphylococcal enterotoxins A - D and the toxic shock syndrome toxin - 1 have been isolated from the skin of up to 65% of AD patients who are colonized with this microorganism. These toxins aggravate the disease by cellular activation to produce cytokines. en_US
dc.language.iso en en_US
dc.subject Atopic dermatitis en_US
dc.subject Staphylococcus aureus en_US
dc.subject Colonization en_US
dc.subject Superantigens en_US
dc.subject T-cells en_US
dc.subject Cytokines en_US
dc.title Role of Staphylococcus aureus in Atopic Dermatitis en_US
dc.type Article en_US

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