Comparative cytotoxicity of selected cyanotoxins on Human Embryonic Kidney (HEK 293) and Human Kidney Adenocarcinoma (ACHN) Cells.
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ISOI Journal Of Microbiology, Biotechnology And Food Science
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The aim of present study was to evaluate the cytotoxic effects of some selected cyanotoxins namely, MC-LR, MC-RR, MC-LF, MC-LW and Nodularin on normal human kidney cells (HEK-293) and human kidney adenocarcinoma cells (ACHN). Cells were exposed to different concentrations of (1.0-200 pM ) cyanotoxin variants for 24 h and the cytotoxic effects were evaluated by Sulphorhodamine B (SRB) assay. Overall findings of the study demonstrate that cyanotoxins could cause cytotoxic effects on kidney cells. MC-LR was the most toxic while MC-LW was least toxic cyanotoxin on both cell types tested. MC-RR, MC-LF and Nodularin had moderate cytotoxicity on human renal cells.
The aim of present study was to evaluate the cytotoxic effects of some selected cyanotoxins namely, MC-LR, MC-RR, MC-LF, MC-LW and Nodularin on normal human kidney cells (HEK-293) and human kidney adenocarcinoma cells (ACHN). Cells were exposed to different concentrations of (1.0-200 pM ) cyanotoxin variants for 24 h and the cytotoxic effects were evaluated by Sulphorhodamine B (SRB) assay. Overall findings of the study demonstrate that cyanotoxins could cause cytotoxic effects on kidney cells. MC-LR was the most toxic while MC-LW was least toxic cyanotoxin on both cell types tested. MC-RR, MC-LF and Nodularin had moderate cytotoxicity on human renal cells.
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Piyathilaka, P.C., Tennekoon, K.H., De Silva, N.K., Manage, P.M. (2016). "Comparative cytotoxicity of selected cyanotoxins on Human Embryonic Kidney (HEK 293) and Human Kidney Adenocarcinoma (ACHN) Cells.", ISOI Journal Of Microbiology, Biotechnology And Food Science, Vol.2 (1), pp. 45-49