Abstract:
Icon® is a type II synthetic pyrethroid insecticide based on active ingredient
Lambda cyhalothrin (10% w/w). In a recent study it was evident that this
insecticide although induced marked signs of stress and other overt signs of
toxicity in pregnant rats it never provoked aversive behaviours: suggestive
of antinociceptive activity. Hence this study was conducted to investigate
the possible antinociceptive potential of leon® on pregnant rats. Different
doses ofIcon® 0, 63,83 or 125 mg/ kg body weight/day (active ingredient
0,6.3,8.3, 12.5 mg / kg body weight/day) was orally administered to pregnant
(early, mid and late) rats for seven consecutive days and antinociception
potential was determined using the hot plate technique. The results showed
a marked antinocicpetive activity (in terms of prolongation of reaction time)
of leon in pregnant rats. It is concluded that the antinociception is mediated
by both specific (neuronal) and non specific (stress and food inhibition)
mechanisms.
