Abstract:
Patoladi Ghanasara (PG) consisting of five ingredients (Termimlia chebule
Retz; Terminania belarica Roxb; Phillenthus emblica Linn; Tricosenthus
cucumarina Linn; Azadirachta indica A Juss) is recommended for the
treatment of gastric lesions (Amlapitta) in Ayurvedic medicine. Recently,
we showed using rat ethanol-induced gastric lesion technique that Patoladi
decoction has strong gastroprotective activity when given orally. The aim
of this study was to investigate whether semisolid preparation of this
decoction, namely (PG) has gastroprotective activity when assessed with
the same technique and method of administration. Three different
concentrations of the PG were used: 30%, 15% and 7.5%. The results show
that PG has overall gastroprotective activity but is less effective than PD (in
terms of both number and length of gastric haemorrhgic lesions).
