Attached
introduction
Nutritional and immune status is important in
the outcome of surgical and non-surgical
diseased conditions.
Objectives
To correlate nutritional and immune markers
with development of post-operative
infections in patients who had undergone
CABG.
Method
Pre and post-operative nutritional (vitamins A
and E, serum ferritin, albumin) and immune
markers (Total Antioxidant Capacity (TAC), IL6) of patients (n=102) at Cardid-Thoracic Unit,
SJGH were determined. Data on surgical site
and other infections were collected from BHT.
Results
Significantly (p=0.003) high percentage of
females (40%) developed infections. Patients
with post-op infections (POI) had significantly
high pre (p=0.02) and post-operative (p=0.01)
TAC. Pre-operative cutoff of 5.9 TEAC
pg/lOOg and post-operative cut-off of 6.6
TEAC pg/lOOg could predict development of
POI. Significantly (p=0.006) high
concentration of post-operative IL-6 was
observed in patients POI. Patients who
developed POI had positive correlation
between pre-operative TAC and pre (r=0.45,
p=0.02) and post (r=0.44, p=0.02) operative
albumin. When compared with individuals
without infections, the odds ratios of
decreased pre-operative albumin (1.2,95% Cl
1-1.3), elevated post-operative IL-6 (1,95% Cl 0.9-1.0) and pre-operative TAC (0.6, 95% Cl
0.39-0.98) associated with POI.
Conclusions
Pre and post-operative TAC could predict true
positive incidence of POI with moderately
high specificity and true negative incidence of
POI with a moderately high sensitivity
respectively. Post-operative IL-6 could be a
predictor for development of POI following
CABG.
