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Obesity leads to the development of insulin resistance (IR), impaired glucose tolerance
and type 2 Diabetes Mellitus (T2DM) resulting from a low-grade inflammation of white
adipose tissue. This study was cond ucted to identify the association of anthropometric
parameters and bio-impedance analysis (BIA), which are used as markers of obesity,
with IR and T2DM. A female population living in Elahera divisional secretariat area
was selected using convenient sampling method [25 T2DM subjects and 25 nondiabetic subjects; mean age=41±6 years). Height, Weight, Waist Circumference (WC),
Hip Circumference was estimated using standard protocols and Body Mass Index
(BMI) and Waist-to-Hip Ratio (WHR) were calculated. Body Fat percentage (BF%),
Visceral Fat level (VF), whole body Subcutaneous Fat percentage (SF%) and whole
body Skeletal Muscle percentage (SM%) were assessed using BIA (OMRON HBF-362)
analyser. Ten hour fasting blood samples were analysed for fasting blood sugar (FBS)
and Insulin level using kits. IR was calculated using HOMA-IR equation (homeostatic
model assessment). HOMA-IR values >2.6 were considered as insulin resistant. Mean
IR values among T2DM subjects and controls were 4.5 and 2.5 respectively (p=<0.05).
80% of diabetic subjects and 20% of non-diabetic individuals were insulin resistant
showing statistically significant association. Only WC and WHR showed significant
difference among non-diabetic individuals and diabetic subjects [(p=<0.05) (WC=81.4
cm, 87.4 cm: WHR = 0.87, 0.91 among non-diabetic individuals and diabetic subjects
respectively)]. However, when the whole population was divided in to tw o groups
based on having and not having insulin resistance, BMI, WC, BF%, SF%, and VF levels
(p<0.05) were significantly higher in the insulin resistant group compared to the
rion-insulin resistant group (BMI=22.5, 26.2: WC=80.0 cm, 88.1 cm: BF%=32.6, 35.1:
SF%=26.6, 30.7: VF=5.57, 8.11 respectively among non-insulin resistant and insulin
resistant groups). Thus, the data indicates that the anthropometric parameters
and body fat levels are better associated with insulin resistance rather than Type 2
diabetes mellitus.
