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Association of Markers of Obesity with Insulin Resistance and Type 2 Diabetes Mellitus in a Rural Female Population

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dc.contributor.author Rathnayake, R.G.L.
dc.contributor.author Hettiaratchi, U.P.K.
dc.contributor.author Perera, P.P.R.
dc.date.accessioned 2017-11-06T03:39:58Z
dc.date.available 2017-11-06T03:39:58Z
dc.date.issued 2016
dc.identifier.citation Rathnayake, R.G.L., Hettiaratchi, U.P.K., Perera, P.P.R. (2016). "Association of Markers of Obesity with Insulin Resistance and Type 2 Diabetes Mellitus in a Rural Female Population", Proceedings of 9th International Research Conference, KDU, Sri Lanka, 8th - 9th Sept 2016, p. 157 en_US, si_LK
dc.identifier.uri http://dr.lib.sjp.ac.lk/handle/123456789/6484
dc.description.abstract Attached en_US, si_LK
dc.description.abstract Obesity leads to the development of insulin resistance (IR), impaired glucose tolerance and type 2 Diabetes Mellitus (T2DM) resulting from a low-grade inflammation of white adipose tissue. This study was cond ucted to identify the association of anthropometric parameters and bio-impedance analysis (BIA), which are used as markers of obesity, with IR and T2DM. A female population living in Elahera divisional secretariat area was selected using convenient sampling method [25 T2DM subjects and 25 nondiabetic subjects; mean age=41±6 years). Height, Weight, Waist Circumference (WC), Hip Circumference was estimated using standard protocols and Body Mass Index (BMI) and Waist-to-Hip Ratio (WHR) were calculated. Body Fat percentage (BF%), Visceral Fat level (VF), whole body Subcutaneous Fat percentage (SF%) and whole body Skeletal Muscle percentage (SM%) were assessed using BIA (OMRON HBF-362) analyser. Ten hour fasting blood samples were analysed for fasting blood sugar (FBS) and Insulin level using kits. IR was calculated using HOMA-IR equation (homeostatic model assessment). HOMA-IR values >2.6 were considered as insulin resistant. Mean IR values among T2DM subjects and controls were 4.5 and 2.5 respectively (p=<0.05). 80% of diabetic subjects and 20% of non-diabetic individuals were insulin resistant showing statistically significant association. Only WC and WHR showed significant difference among non-diabetic individuals and diabetic subjects [(p=<0.05) (WC=81.4 cm, 87.4 cm: WHR = 0.87, 0.91 among non-diabetic individuals and diabetic subjects respectively)]. However, when the whole population was divided in to tw o groups based on having and not having insulin resistance, BMI, WC, BF%, SF%, and VF levels (p<0.05) were significantly higher in the insulin resistant group compared to the rion-insulin resistant group (BMI=22.5, 26.2: WC=80.0 cm, 88.1 cm: BF%=32.6, 35.1: SF%=26.6, 30.7: VF=5.57, 8.11 respectively among non-insulin resistant and insulin resistant groups). Thus, the data indicates that the anthropometric parameters and body fat levels are better associated with insulin resistance rather than Type 2 diabetes mellitus.
dc.language.iso en_US en_US, si_LK
dc.publisher Proceedings of 9th International Research Conference, KDU, Sri Lanka, 8th - 9th Sept 2016 en_US, si_LK
dc.subject Insulin Resistance en_US, si_LK
dc.subject Type 2 Diabetes Mellitus en_US, si_LK
dc.subject Obesity en_US, si_LK
dc.title Association of Markers of Obesity with Insulin Resistance and Type 2 Diabetes Mellitus in a Rural Female Population en_US, si_LK
dc.type Article en_US, si_LK


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