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Studies have shown that elevated levels o f
fasting blood glucose (FBS) fasting serum
insulin (FSI) fasting serum C-peptide (FSCpepetide) and insulin resistance (IR) are seen in
hypertensive subjects. The aim o f this study
was to compare FBS, FSI, and FSC- peptide
among hypertensive and non- hypertensive
individuals.
Age sex matched case control study was
carried out at the Family Practice Center o f
University o f Sri Jayewardenepura in a nondiabetic population, aged 35-55 years
(hypertensive-30, non-hypertensive-30). After
an overnight fast (10 h) 2 mL venous blood
was collected and FBS was analyzed using
glucose oxidase kit, FSI and FSC- peptide
were analyzed using -ELISA kit. IR w as*
calculated using Homeostasis Model o f
Assessment-IR equation (HOMA-IR = Fasting
insulin (pU/ml)xFasting glucose
(mmol/l)/22.5). Data was analyzed using
student t-test, with SPSS 16.
Mean values o f FBS, FSI, FSC-peptide and IR
in hypertensives were 91.8±19.6 mg/dL,10.5±
7.2 pU/mL,2.3± 1.4ng/mL, 2.5±1.9 and in non
-hypertensives, 81.8±10.9 mg/dL, 7.0±4.2
pU/mL, 1.4±0.8 ng/mL, 1.5±1.1 respectively.
The means o f measured parameters were below
the risk cutoff in both groups. Only FSC- peptide
had statistically significant difference
(P=0.003) between the two groups while the
other mean values o f hypertensives -were
higher - compared to non-hypertensives. —In
addition, only among hypertensives, the
following percentage had above the risk cut
off levels, 23.3% (FSI), 13.3 % (FSC-peptide)
and 36.6% (IR).
