Effect of Carbachol on Fertility of Male Rats When Administered Locally to Epididymis

Abstract

This study examines the effect of carbachol, a potent cholinoceptor agonist drug, on fertility of male rats, when administered to epididymis using stlastic formulations, in the form of rods. 10% and 25% carbachol rods were found to be toxic, and resulted in death within 25 min. On the other hand, 5% rods were tolerable. These rods significantly reduced sperm numbers both in the cauda epididymis and ejaculate but failed to Impair fertility. Libido (sexual desire) remained essentially unaltered. In organ bath experiments, carbachol induced rhythmic contrations in isolated vasa deferentia and cauda epididymal tubules in a ' dose-related manner.