Abstract:
This study examines the effect of carbachol, a potent cholinoceptor agonist
drug, on fertility of male rats, when administered to epididymis using stlastic
formulations, in the form of rods. 10% and 25% carbachol rods were
found to be toxic, and resulted in death within 25 min. On the other hand,
5% rods were tolerable. These rods significantly reduced sperm numbers
both in the cauda epididymis and ejaculate but failed to Impair fertility.
Libido (sexual desire) remained essentially unaltered. In organ bath experiments,
carbachol induced rhythmic contrations in isolated vasa deferentia
and cauda epididymal tubules in a ' dose-related manner.
